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Biochemistry (Lange USMLE Road Map Series)

by Richard G. MacDonald,William G. Chaney

Publisher: McGraw-Hill Medical/Jaypee Brothers Medical Publishers

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You'll never find an easier, more efficient, and more focused way to ace biochemistry and biochemistry-related questions on the USMLE and course examinations than the USMLE Road Map. Designed to provide maximum learning in minimum time, this fully updated USMLE Road Map offers a concise, creative, and well-illustrated approach to mastering biochemistry. Table of contents 1. Physiological Chemistry and Bonding A. Water as biochemical solvent B. Hydrogen bonding C. pH and buffers D. Other non-covalent interactions E. Fat-water interfaces2. Protein Structure and Function A. Amino acids B. Primary structure—protein sequence C. Secondary structures—?-helix and ?-sheet D. Tertiary structure—domains E. Quaternary structure—subunits F. Fibrous proteins—collagen and elastin G. Globular proteins—myoglobin and hemoglobin H. Folding and chaperones3. Enzyme Structure and Function A. Types of enzymes—classification B. Kinetics—Michaelis-Menten enzymes C. Inhibition D. Allosteric regulation E. Mechanisms—chymotrypsin and ribonuclease4. DNA Structure and Function A. Purine and pyrimidine bases B. The DNA molecule C. Packaging into chromatin D. Replication E. Recombination and repair 5. RNA Structure and Function A. RNA structures—mRNA, rRNA, tRNA B. Transcription C. Splicing D. Ribonucleoprotein complexes 6. DNA and Chromosome Analysis A. Hybridization B. Nucleic acid electrophoresis C. Northern and Southern blotting D. RFLP analysis E. Polymerase chain reaction F. Allele-specific oligonucleotides G. Fluorescence in situ hybridization7. Control of Gene Expression A. The lac operon B. The Trp operon C. Eukaryotic promoters, enhancers and repressors D. Transcription factors E. Methylation and acetylation8. Protein Biosynthesis, degradation and trafficking A. Translation B. Post-translational modification C. Secretion D. Intracellular targeting E. Lysosomal degradation F. Proteosomal degradation 9. Biological Membranes A. The lipid bilayer B. Transport C. Junctions and intercellular communication 10. Cytoskeleton and Extracellular Matrix A. Microtubules and microfilaments B. Integrins and focal adhesions C. Extracellular matrix proteins D. Proteoglycans and glycosaminoglycans E. Motility11. Overview of Metabolic Relationships A. Digestion of nutrients B. Catabolism vs. anabolism C. Carbohydrates D. Lipids12. Carbohydrate Metabolism A. Glycolysis B. Anaerobic glycolysis C. Aerobic glycolysis D. Pentose Phosphate Pathway13. Hexose Regulation A. Gluconeogenesis B. Glycogen biosynthesis and glycogenolysis C. Hexose metabolism14. Pyruvate Oxidation A. Biosynthesis of Acetyl-CoA B. Steps of the TCA Cycle C. Regulation of Pyruvate dehydrogenase D. Regulation of the TCA cycle15. Oxidative Phosphorylation A. Transfer of electrons to Complex I B. Delivery of electrons through Complex II C. Ubiquinone and common steps in electron transfer D. Creation of a pH gradient during electron transfer E. Utilization of the pH gradient to form ATP F. Inhibitors of ATP biosynthesis G. Stoichiometry of ATP biosynthesis16. Lipid Metabolism A. Fatty acid biosynthesis B. Fatty acid degradation C. Formation of triglycerides D. Glycolipid biosynthesis E. Eicosanoid biosynthesis F. Cholesterol Biosynthesis G. Lipoproteins 17. Amino Acid Metabolism A. Nitrogen metabolism B. Essential amino acids C. Catabolism of amino acids D. Biosynthesis of amino acids E. Biosynthesis of porphyrins 18. Nucleic Acid Metabolism A. Biosynthesis of purines B. Biosynthesis of pyrimidines C. Biosynthesis of deoxynucleotides D. Salvage pathways of bases E. Degradation of purines F. Degradation of pyrimidines 19. Nutritional Biochemistry A. General Nutritional Requirements B. Vitamins 1. Water-soluble 2. Fat-soluble C. Essential inorganic nutrients D. Essential amino acids E. Essential lipids20. Receptors and Signal Transduction A. Overview of receptors and ligands B. Types of receptors C. Nuclear receptor superfamily D. Membrane receptors 1. G protein-coupled receptors 2. Growth factor receptors E. Nitric oxide F. Protein kinase A G. Protein kinase C H. Calcium-calmodulin signaling I. Kinase cascades 21. Cancer Biology A. Overview of cancer as a genetic disease B. Definitions C. Chemical carcinogenesis D. Radiation-induced DNA damage 1. Ionizing radiation—x-rays, gamma rays 2. Ultraviolet radiation E. Oncogene activation F. Tumor suppressors G. Programmed cell death—apoptosis

Details of the book

Book :
Biochemistry (Lange USMLE Road Map Series)
Book ID :
40718
Author :
Richard G. MacDonald,William G. Chaney
ISBN 13 :
9780071442053
Year of Publication :
2007
Edition :
First
Publisher :
McGraw-Hill Medical/Jaypee Brothers Medical Publishers
Binding :
Softcover
Pages :
224
Weight :
1 kg

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